Nachmani Daphna

Dr. Daphna Nachmani
Translation regulation by RNA modifications in development and disease
Genetics

Personal Information

Research Interests

Our goal is to better understand the regulatory role of the ribosome in the central dogma of gene expression.
We explore molecular mechanisms of translation-regulation; specifically focusing on the role of RNA modifications in translational control during normal hematopoietic development, leukemia initiation, and viral infection.

Dissertation Topics

  1. The role of RNA modifications in translation regulation – how rRNA modifications control ribosome function and its translational capacity?
  2. Hematopoiesis – We aim to understand how translation-regulation, by the ribosome, controls hematopoietic stem cell function and the generation of blood cells.  
  3. Ribosome hijacking during Viral infection – We explore how pathogens, like viruses, utilize the host’s ribosome to their own advantage to facilitate viral replication and disease manifestation.  
 
Dr. Daphna  Nachmani

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02-65-
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Silberman 3-606