We use the zebrafish embryo as an in-vivo model to study RNA biology of vertebrate development. Changes in the RNA content of embryonic pluripotent cells lead them to assume more specialized identities. Large efforts strive to understand how the ‘birth’ of RNA (transcription) direct developmental changes, but less is known about the regulation of RNA after its production: during RNA splicing, localization, and ‘death’ by degradation. The zebrafish embryo provides important research advantages in easy manipulations through microinjection, large numbers of embryos and powerful imaging tools within optically transparent embryos.
Research Overview (176.47 KB)