1. The mechanisms underlying different patterns of chromosomal instability in cancer. 

• How alterations in the transcriptional profile, DNA replication timing and the 3D genome organization drive tumorigenesis?
• The involvement of chromosomal fragile sites in the genomic instability in cancer.

2. Personalized medicine approach for the treatment of rare genetic diseases – CF as a model.

• Establishment of patient-derived cellular models that will serve as a pre-clinical tool to predict the therapeutic response of CF patients carrying rare mutations to novel therapies.
• Development of novel therapeutic approaches for CF patients carrying nonsense mutations  -  RNA transcript stabilization by epigenetic modulation.