Engelberg David

Prof. David Engelberg

Developmental Mechanisms of inflammatory Diseases & Cancer

Biological Chemistry

Personal Information

Research Interests

Development of constitutively active MAP/stress kinases for studies of the etiology cancer and inflammation. Revealing the mechanism of gene expression under stress in yeast and mammalian cells. Focusing on Gcn4, Hsf1 and Msn2/4. Analysis expression of stress-related genes in oncogenically-transformed cells.

Dissertation Topics

Development of intrinsically active variants of the MAP kinases p38 and ERK.
Revealing the mechanisms of activation of p38 and ERK through the use of the engineered active variants.
Revealing the specific roles of ERK1 and ERK2 in cancer in cell lines and in transgenic mice.
Revealing the specific role of p38 in chronic inflammatory diseases in cell lines and in transgenic mice.