Our lab investigates the molecular mechanisms underlying neurodegenerative diseases known as tauopathies, such as Alzheimer’s disease, with the goal of understanding disease progression and developing innovative therapeutic strategies. Our research focuses on uniquely structured protein aggregates called amyloids, particularly those formed by the tau protein, which play a central role in these disorders. We integrate biochemistry, structural biology (cryo-EM and X-ray crystallography), and cellular models to uncover the processes that drive amyloid formation and propagation in the brain and to identify therapeutic points of intervention.