The Hebrew University of Jerusalem
Dr. Julia Shifman
The Protein Design Lab
 
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Recent Publications
  • Shifman J. M., Choi M. H., Mihalas, S., Mayo S. L., and Kennedy M. B. (2006) Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums. Proc. Nat. Acad. Sci. USA 103(38) 13968-13973. 

  • Yanover C., Fromer M., and Shifman J. M. (2007) Dead-End Elimination for Multi-state Protein Design, J. Comp. Chem., 28 (13) 2122-2129.

  • Shifman J. M. (2008) Intricacies of beta-sheet protein design, Structure 16, 1751-1752

  • Yosef E., Politi R., Choi M. H., and Shifman, J. M. Computational design of calmodulin mutants with up to 900-fold increase in binding specificity (2009), J. Mol. Biol., 385, 1470-1480.

  • Shifman J. M. and M. Fromer (2009) Search algorithms in Protein Engineering and Design, (S. Park and J. Cochran, Eds), Taylor & Francis. Boca Raton, 293-312.

  • Shifman J. M. (2009) Computational design of protein-protein interactions in Computational Protein-Protein interactions, ed. Gideon Schreiber and Ruth Nussinov. Taylor & Francis, CRC press, 129-144. 

  • Sharabi O., Peleg Y., Mashiach E., Vardy E., Ashani Y, Silman I., Sussman J. L., and Shifman J. M. (2009) Design, expression, and characterization of mutants of fasciculin optimized for interaction with its target acetylcholinesterase, Prot. Eng. Des. Sel., 22, 641-648. 

  • Fromer M. and Shifman J. M. (2009) Tradeoff between stability and multispecificity in design of promiscuous proteins, PLoS Comp. Biol., 5(12) e1000627.

  • Sharabi O., Yanover C., Dekel A., and Shifman J. M. (2010) Optimizing energy functions for design of protein-protein interfaces, J. Comp. Chem.32(1), 23-32.

  • Filchinski D., Sharabi O., Rueppel A., Vetter I. R., Herrmann, C., and Shifman J. M. (2010) What makes Ras an efficient molecular switch: A biophysical and structural study of Ras-GDP interactions with mutants of Raf, J. Mol. Biol., 399 (3), 422-435.
  • Sharabi O., Dekel A. and Shifman J. M. (2011) Triathlon for energy functions: is there a winner for the design of protein-protein interactions? Prot Struct Funct Bioinf, in press.
    • Erijman A. Aizner Y and Shifman J. M. (2011) Multispecific recognition: mechanisms, evolution, and design, Biochemistry, 50 (5), 602-611.
  • Erijman A., Dantes A, Shifman J. M. and Peleg Y. (2011) Transfer PCR (TPCR) - a highway for cloning and protein engineering, submitted
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